Redox Regulation of γ-Glutamyl Transpeptidase
نویسندگان
چکیده
منابع مشابه
Expression and regulation of γ-glutamyl transpeptidase-related enzyme in tracheal cells.
Glutathione plays an essential role in protecting the pulmonary system from toxic insults. γ-Glutamyl transpeptidase-related enzyme (GGT-rel) is a novel protein capable of cleaving the γ-glutamyl peptide bond of glutathione and of converting leukotriene C4 to leukotriene D4. A rat homologue of GGT-rel was identified and was found to be highly expressed in cultures of differentiating rat trachea...
متن کاملInhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors.
GGT (γ-glutamyl transpeptidase) is an essential enzyme for maintaining cysteine homoeostasis, leukotriene synthesis, metabolism of glutathione conjugates and catabolism of extracellular glutathione. Overexpression of GGT has been implicated in many pathologies, and clinical inhibitors of GGT are under development for use in the treatment of asthma, cancer and other diseases. Inhibitors are gene...
متن کاملFluctuations of Γ-glutamyl Transpeptidase in Normal and Cataractous Human Eye
The most common form of cataract is the “Senile Cataract” occurring in the aged population, which has great socio-medical prevalence for many third world countries, where annually 2-3 million people become blind due to cataract. The cause and phenomenon of cataract development may be same but the changes related with γglutamyl transpeptidase (GTP) activity depends on age and types of cataract. ...
متن کاملProtective efficacy of vaccines based on the Helicobacter suis urease subunit B and γ-glutamyl transpeptidase.
Helicobacter suis causes gastric lesions in pigs and humans. This study aimed to evaluate the protective efficacy of immunization with combinations of the H. suis urease subunit B (UreB) and γ-glutamyl transpeptidase (GGT), both recombinantly expressed in Escherichia coli (rUreB and rGGT, respectively). Mice were intranasally immunized with rUreB, rGGT or a combination of both proteins, adminis...
متن کاملCovalent Immobilization of Bacillus licheniformis γ-Glutamyl Transpeptidase on Aldehyde-Functionalized Magnetic Nanoparticles
This work presents the synthesis and use of surface-modified iron oxide nanoparticles for the covalent immobilization of Bacillus licheniformis γ-glutamyl transpeptidase (BlGGT). Magnetic nanoparticles were prepared by an alkaline solution of divalent and trivalent iron ions, and they were subsequently treated with 3-aminopropyltriethoxysilane (APES) to obtain the aminosilane-coated nanoparticl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2009
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2009-0169tr